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J Frailty Aging · 2022

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de Souto Barreto P, Cesari M, Morley JE, Roberts S, Landi F, Cederholm T, Rolland Y, Vellas B, Fielding R

Appetite Loss and Anorexia of Aging in Clinical Care: An ICFSR Task Force Report

11(2). 129-134.

DOI PMID: 35441188 Open original source
Study type
Expert task force report
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Full text reviewed

Losing interest in food in later life can matter before a person visibly loses weight. Appetite loss is associated with malnutrition, reduced physical function, and frailty, a state of increased vulnerability to health problems. This report argues that it should be assessed routinely rather than dismissed as an inevitable part of aging. In screening data from 4,546 adults aged 60 or older in one French region, only about 45% of those reporting appetite loss also reported unintentional weight loss. Relying on weight change alone would therefore overlook many people whose appetite had already declined.

Poor appetite has several possible contributors, including illness, medicines, chewing or swallowing problems, depression, and social isolation. The screening data linked appetite loss with difficulties across physical and mental functions, even after accounting for age and sex. These associations do not prove that appetite loss caused those difficulties. They support treating appetite as part of a broader assessment of the person’s health and circumstances.

How Does This Show Up in Real Life?

For an older person or someone supporting them, the report makes changes in appetite a useful subject to raise during routine care, even when the bathroom scale looks unchanged. An assessment can explore whether eating has become uncomfortable, food is difficult to obtain or prepare, or mood and loneliness have changed. The authors favor addressing these contributing problems and considering nutritional support within clinical care. They describe options such as food fortification or oral nutritional supplements, but do not establish one solution for everyone. Lower energy needs with age also do not mean that the need for essential nutrients disappears. The practical message is to look at what and how much the person can actually eat, alongside their function and health, rather than judging nutrition from body weight alone.

The recommendations combine expert judgment with existing research and screening observations, rather than demonstrating the benefit of a single treatment. Energy-expenditure data in very old adults are sparse and often compare different people instead of following individuals over time. Available appetite drugs had an unfavorable or uncertain balance of benefit and harm, and better trials of both drug and non-drug approaches were needed.

The report supports taking a persistent appetite change seriously without treating it as a diagnosis by itself. Its strongest contribution is a broader approach to assessment. Whether a particular intervention improves appetite, strength, independence, or longer-term health still needs to be judged with evidence specific to that intervention.

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