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Current Neuropharmacology · 2015

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Simone Cappelletti, Piacentino Daria, Gabriele Sani, Mariarosaria Aromatario

Caffeine: Cognitive and Physical Performance Enhancer or Psychoactive Drug?

Bentham Science Publishers Ltd.. 13(1). 71-88.

Study type
Narrative review
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Full text reviewed

Feeling sharper after caffeine does not always mean performing above your usual baseline. The authors examine possible cognitive and physical benefits alongside dependence, anxiety, and toxicity. Caffeine can promote alertness, but some apparent improvement in regular users may reflect relief from withdrawal. The paper describes withdrawal beginning about 12–24 hours after stopping, often peaking at 24–48 hours and lasting around a week. These timings describe reported patterns, not a prediction for every person. The central distinction is between a substance having useful effects in some settings and being harmless or reliably helpful in all settings.

Caffeine's effects depend on the task, the dose, and the person's prior exposure. Staying awake or responding faster is not equivalent to improving every kind of thinking. Physical-performance findings do not automatically establish a cognitive benefit either. Dependence and adverse effects deserve attention, but regular use alone does not show that everyone has a disorder. The evidence does not support either an all-benefit or an all-harm description.

How Does This Show Up in Real Life?

Consider a morning when you skip your usual coffee and feel unusually tired or develop a headache. Feeling better after having caffeine could reflect a return toward your accustomed state, rather than a new gain in ability. That possibility changes how a personal comparison should be interpreted. It does not diagnose dependence from one bad morning. The same distinction matters when judging a claim about productivity: was the comparison made with well-rested people at their normal baseline, or with regular users who had temporarily stopped caffeine? The paper encourages that question without providing a self-test or a personalized stopping schedule. It also gives no reason to assume that a larger dose will produce a larger useful benefit. Feeling stimulated and accomplishing a particular task remain different outcomes.

The evidence covers varied experiments, observational findings, and case reports rather than a single consistent comparison. Habitual intake and withdrawal can complicate performance results. Reports of serious intoxication are important warnings, but cannot establish its frequency in the general population. The article does not demonstrate that short-term performance changes become lasting improvements after caffeine use ends.

Why We Cite It

Alpekin can use the paper to explain why the same stated intake may affect people differently. Caffeine breakdown, other substances, and underlying conditions all enter the authors' safety discussion. This adds a concrete limit to personalization based only on a dose, without implying that a consumer tool can predict an individual's sensitivity.

Judge a claimed benefit by the outcome that was actually tested and the comparison used. The evidence warrants attention to both usefulness and downside. It does not turn an everyday habit into proof of superior performance, or into a diagnosis on its own.

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